Omeprazole affects neither electroconvulsive threshold nor anticonvulsant activity of diphenylhydantoin and carbamazepine in mice.

Omeprazole is a commonly prescribed drug for patients with peptic ulcerations. Its main mechanism of action is related to inhibition of H(+)-K(+)-ATP-ase, albeit it may also block carbonic anhydrase. This study evaluates the effects of acute and prolonged (3- or 7-day) intragastrical administration of omeprazole on the anticonvulsant activity of carbamazepine or diphenylhydantoin against maximal electroshock-induced seizures in mice. Omeprazole administered acutely, for 3 days or 7 days did not alter the electroconvulsive threshold in mice. Moreover, the drug did not affect the anticonvulsant activity of the tested antiepileptic drugs.